5-Amino-1MQ

5-Amino-1MQ is a small-molecule compound studied primarily for its role in inhibiting nicotinamide N-methyltransferase (NNMT)—an enzyme heavily implicated in metabolic dysfunction, insulin resistance, obesity, and aging-related degeneration. By suppressing NNMT activity, 5-Amino-1MQ may upregulate cellular NAD+ levels and enhance key methylation pathways, which are vital in regulating cellular energy, repair, and gene expression.

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Description

Disclaimer: This is a research chemical only. It’s not a medication, and it’s not approved for human or animal use outside of authorized studies

Sequence Tyr‑{Aib}‑Glu‑Gly‑Thr‑Phe‑Thr‑Ser‑Asp‑Tyr‑Ser‑Ile‑{Aib}‑Leu‑Asp‑Lys‑Ile‑Ala‑Gln‑{diacid‑C20‑γ‑Glu‑(AEEA)₂‑Lys}‑Ala‑Phe‑Val‑Gln‑Trp‑Leu‑Ile‑Ala‑Gly‑Gly‑Pro‑Ser‑Ser‑Gly‑Ala‑Pro‑Pro‑Pro‑Ser‑NH₂ (Tirzepatide, 39 aa peptide with C20 fatty acid)
Molecular Formula C₂₂₅H₃₄₈N₄₈O₆₈
Molecular Weight ~4813.5 Da
PubChem CID 156588324
CAS # 2023788‑19‑2

In laboratory research, 5-Amino-1MQ has been explored for its potential to stimulate lipolysis, increase lean muscle retention, and improve metabolic flexibility in models of caloric excess, insulin resistance, and muscle atrophy. It is also of interest in studies examining sarcopenia, mitochondrial dysfunction, and aging-induced performance decline.

Unlike many peptides or biologics, 5-Amino-1MQ is a low–molecular weight molecule, offering researchers a distinct pharmacokinetic profile and simplified delivery routes. Early-stage data in vitro and in animal studies suggest this compound may support improved body composition, muscle regeneration, and fat loss via epigenetic modulation—especially when studied in tandem with NAD+ precursors or exercise protocols.

Researchers value 5-Amino-1MQ for its cross-disciplinary relevance across aging, metabolism, and performance studies, as well as its novel mechanism targeting NNMT—one of the lesser-known metabolic “master switches” currently under investigation.

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