Description

Disclaimer: This is a research chemical only. It’s not a medication, and it’s not approved for human or animal use outside of authorized studies

AOD-9604 is a synthetic peptide fragment derived from the C-terminal region of human growth hormone (HGH), specifically residues 177-191, but without the mitogenic or hyperglycemic effects traditionally associated with HGH itself. This structural distinction makes AOD-9604 an important investigational tool for studying selective metabolic pathways.

Researchers have examined AOD-9604 primarily for its ability to stimulate lipolysis (the breakdown of stored fat) while simultaneously inhibiting lipogenesis (the formation of new fat tissue). Notably, studies indicate that AOD-9604 does not significantly impact blood glucose regulation or lean muscle synthesis, making it distinct from full-length HGH in its activity profile.

Mechanistically, AOD-9604 has been shown to act through beta-3 adrenergic receptor signaling and lipid mobilization cascades, providing a model for exploring fat metabolism without the broader systemic risks of traditional GH therapies. In preclinical and early-stage models, it has also been evaluated for potential effects on cartilage repair and bone metabolism, broadening its scope beyond metabolic research alone.

Because of its stability and selective activity, AOD-9604 continues to be studied as a candidate for investigating obesity-related pathways, metabolic regulation, and tissue-specific therapeutic approaches.