KPV is a naturally derived tripeptide built from three amino acids—Lysine, Proline, and Valine. Researchers are drawn to this peptide because of its role in controlling how the body responds to stress and inflammation. It’s studied for the way it helps “dial down” overactive immune responses while supporting healthier recovery processes in tissues.
In laboratory settings, KPV has been explored for its ability to calm inflammatory signaling pathways and assist in protecting cells from damage caused by excessive immune activity. This makes it of particular interest in research models related to skin, gut, and epithelial tissue function. Because of its small size and natural stability, it’s also a convenient tool for researchers studying localized immune response and tissue repair.
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Disclaimer: This is a research chemical only. It’s not a medication, and it’s not approved for human or animal use outside of authorized studies
| Sequence | Lys‑Pro‑Val (KPV), α‑MSH fragment (amino acids 11–13) |
| Molecular Formula | C₁₆H₃₀N₄O₄ |
| Molecular Weight | ~342.4 g/mol |
| PubChem CID | 16132320 |
| CAS # | 67727‑97‑3 |
KPV (Lysine–Proline–Valine) is a naturally occurring tripeptide derived from the C-terminal sequence of the α-melanocyte–stimulating hormone (α-MSH). In research settings, KPV is studied for its potential anti-inflammatory and immunomodulatory properties, with particular interest in how it influences pathways of cytokine regulation and tissue repair.
In vitro investigations suggest that KPV can interact with key inflammatory mediators, including NF-κB signaling, while also modulating epithelial cell activity involved in barrier function and wound healing. This has led to its examination in models of skin injury, gastrointestinal inflammation, and mucosal protection. KPV’s small molecular size and stability make it a useful probe for exploring mechanisms of innate immune regulation and localized tissue recovery.
Because of these attributes, KPV is increasingly used in laboratory contexts to better understand the interplay between peptide signaling, immune modulation, and tissue regeneration. Its profile has made it a subject of interest for research on conditions where excessive inflammation or impaired healing are central features.
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