Description

Disclaimer: This is a research chemical only. It’s not a medication, and it’s not approved for human or animal use outside of authorized studies

Melanotan II (MT-2) is a synthetic analog of the naturally occurring α-melanocyte–stimulating hormone (α-MSH), designed as a cyclic heptapeptide with enhanced stability and bioavailability compared to its endogenous counterpart. Within controlled research environments, MT-2 has been extensively studied for its interaction with melanocortin receptors, particularly MC1R, MC3R, MC4R, and MC5R. These receptor pathways are of interest because of their roles in pigmentation biology, energy regulation, and central nervous system function.

Laboratory studies frequently examine MT-2 for its capacity to stimulate melanogenesis through MC1R activation, providing a reliable model for investigating melanin production and pigmentation dynamics. Beyond dermatological research, MT-2 is often utilized in metabolic studies due to its influence on appetite regulation and energy balance through the melanocortin-4 receptor (MC4R) pathway. In parallel, neuroendocrinology models explore MT-2’s effect on neuronal circuits tied to sexual function, making it a compound of growing relevance in multiple disciplines.

Pharmacologically, MT-2 demonstrates an extended half-life and greater receptor binding stability than natural α-MSH, which allows researchers to study its effects across longer timeframes and under varied experimental conditions. Its unique structural resilience has made it a valuable tool for mechanistic investigations into melanocortin biology and related physiological processes.