SS-31 is a small research peptide that focuses on protecting and supporting the “power plants” of cells — the mitochondria. In studies, it has been shown to help cells make energy more efficiently, reduce harmful byproducts from stress, and keep the mitochondria stable during injury or aging conditions. What makes SS-31 unique is how it binds directly to a part of the mitochondrial membrane that’s critical for keeping cells healthy and producing energy. By strengthening this structure, SS-31 helps support energy output (ATP production) and protects tissues under stress.
Because of this, researchers are exploring SS-31 in models of aging, heart strain, neurological decline, kidney stress, and other conditions tied to energy loss in cells.
Price range: $47.00 through $162.00
Disclaimer: This is a research chemical only. It’s not a medication, and it’s not approved for human or animal use outside of authorized studies
| Sequence | D‑Arg‑Dmt‑Lys‑Phe‑NH₂ (Elamipretide, SS‑31 / MTP‑131) |
| Molecular Formula | C₃₂H₄₉N₉O₅ |
| PubChem CID | 11764719 |
| CAS # | 736992‑21‑5 |
SS-31 (Elamipretide) is a mitochondria-targeted tetrapeptide that has become a focal point of research into age-related and degenerative conditions. Unlike many compounds that act indirectly, SS-31 is designed to selectively localize to the inner mitochondrial membrane, where it interacts with cardiolipin to stabilize mitochondrial structure and function. This unique mechanism has made it a leading candidate for exploring how mitochondrial dysfunction contributes to disease pathology.
Laboratory investigations have shown SS-31 to improve mitochondrial respiration efficiency, decrease the production of reactive oxygen species (ROS), and inhibit mitochondrial swelling. By modulating cytochrome c release, SS-31 helps preserve cellular integrity under conditions of oxidative or ischemic stress. These attributes position it as a valuable tool for modeling protective strategies against tissue degeneration.
Applications under study include neurological models of age-related cognitive decline, cardiomyopathy, ischemia-reperfusion injury, mitochondrial myopathies, and inherited mitochondrial disorders. Researchers have also investigated its potential in renal studies, particularly for mitigating acute kidney injury and protecting organ function under oxidative stress.
As interest in mitochondrial medicine grows, SS-31 has become one of the most prominent peptides under investigation for its ability to bridge energy metabolism, cellular protection, and regenerative pathways. Its translational potential continues to attract attention in experimental cardiology, neurology, nephrology, and aging research.
| MG | 10 MG, 50 MG |
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