SS-31

SS-31 is a mitochondria-targeting tetrapeptide studied extensively for its potential role in restoring cellular energy output, reducing oxidative stress, and protecting mitochondrial membranes in compromised biological models. Mechanism of Interest: SS-31 is unique in that it selectively associates with cardiolipin, a phospholipid critical to mitochondrial structure and function. By stabilizing cardiolipin, SS-31 helps maintain mitochondrial membrane integrity and supports ATP production, especially under stress or injury conditions.

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Description

Disclaimer:
SS-31 is not a pharmaceutical drug. For research use only. Not for human or veterinary use.

 

Peptide sequence: D‑Arg‑Dmt‑Lys‑Phe‑NH₂ (Elamipretide, SS‑31 / MTP‑131) MilliporeSigma+8TargetMol+8medchemexpress.com+8

Molecular formula: C₃₂H₄₉N₉O₅ TargetMol+15SCBT+15Biosynth+15

Molecular weight: ~639.8 Da MilliporeSigma+1SCBT+1

PubChem CID: 11764719 NovoPro Labs+2Wikipedia+2Wikipedia+2

Correct CAS: 736992‑21‑5

Applications Under Research:

  • Neurological studies on age-related cognitive decline
  • Cardiomyopathy and ischemia-reperfusion models
  • Mitochondrial myopathy and inherited mitochondrial disorders

Kidney protection in acute renal injury studies

Researcher are exploring SS-31 for:

  • Improve mitochondrial respiration efficiency
  • Decrease reactive oxygen species (ROS) production
  • Inhibit mitochondrial swelling and cytochrome c release
  • Reduce tissue degeneration in ischemic and degenerative models

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