Tesamorelin

Tesamorelin is a stabilized, synthetic analog of growth hormone–releasing hormone (GHRH), developed to resist enzymatic degradation and extend its half-life in experimental models. It is composed of 44 amino acids and includes a trans-3-hexenoic acid group that enhances stability and bioactivity in vitro.Tesamorelin is studied for its ability to stimulate endogenous GH release through GHRH receptor activation. Scientists study it because it may offer benefits similar to boosting growth hormone levels—without directly injecting GH itself.
  • Mimics endogenous GHRH with improved pharmacokinetics
  • Half-life extended to ~1–2 hours (vs. minutes for native GHRH)
  • Commonly used in metabolic and age-related disease research
  • Often paired with IGF-1 and GH receptor assays in controlled environments This GH release initiates downstream increases in IGF-1 production, making it a valuable peptide in laboratory investigations focused on:Lipid metabolism and visceral fat reduction pathways
  • GH–IGF-1 axis modeling and endocrine system feedback loops
  • Cognitive performance and neuroprotection mechanisms in aging models
  • Wound healing, tissue regeneration, and protein synthesis under catabolic stress

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Description

Disclaimer: This is a research chemical only. It’s not a medication, and it’s not approved for human or animal use outside of authorized studies.

 

H‑Tyr‑Ala‑Asp‑Ala‑Ile‑Phe‑Thr‑Gln‑Ser‑Tyr‑Arg‑Lys‑Val‑Leu‑Ala‑Gln‑Leu‑Ser‑Ala‑Arg‑Lys‑Leu‑Leu‑Gln‑Asp‑Ile‑Leu‑Ser‑Arg‑Arg‑Ser‑Gln‑Asp‑Asp‑Ala‑Ala‑
Gly‑Glu‑Ser‑Gln‑Ala‑Leu‑Arg‑Gly‑Ser‑Gly (human GHRH‑1‑44 with N‑terminal hexenoic acid) (Tesamorelin)Alfa Chemistry+9pharmaffiliates.com+9Biomol GmbH – Life Science Shop+9DrugBank+3Wikipedia+3PubChem+3

Molecular formula: C₂₂₁H₃₆₆N₇₂O₆₇Spharmaffiliates.com

Molecular weight: ~5135.9 Dapharmaffiliates.com+1abmole.com+1

PubChem CID: 44147413

Correct CAS: 218949‑48‑5

Its resistance to breakdown allows for more consistent in vitro profiles over time, offering researchers a reliable compound to model long-term GH secretion patterns.

What makes Tesamorelin unique is that it’s often studied for its fat-reducing effects, especially around the belly area (visceral fat). It was originally developed for patients with HIV-related fat buildup, but researchers now study it more broadly for how it might support fat loss, cognitive function, and metabolic health.
Tesamorelin helps your body’s system turn up its natural fat-burning and muscle-maintaining processes.

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